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Mesoscale Cell Biology Lab

Organisation is a measurable state.

Explore how concentration, variants and cellular context can alter organisation—without turning puncta into an automatic claim of phase separation or material state.

Module 01 · concentration and context

Change the state before naming the mechanism.

This first module is an explanatory simulation. It establishes the reasoning interface that will later sit beside real microscopy and quantitative measurements.

Derived simulated state

Diffuse / weakly structured

Explanatory simulation · not experimental microscopy

Low-to-intermediate concentration produces a largely diffuse simulated distribution.

Boundary: a concentration-associated punctate transition is an organisational phenotype. It is not, by itself, proof of liquid–liquid phase separation, material state or biological function.
Evidence in motion

Prediction and organisation, side by side.

Proteome-scale prediction

Features beyond disorder.

PICNIC connects sequence-derived features to proteome-scale condensate prediction. Developed with the Tóth-Petróczy Lab at MPI-CBG. Open TRIMCode context →
Scale in motion

What the mesoscale means.

The organisational scale between single molecules and whole cells, where concentration, context and collective behaviour decide cellular state.