TRIMCODE FRAMEWORK

Architecture → organisation → perturbation

A whole-family learning framework for inspecting how modular protein architecture becomes context-dependent cellular organisation—and where observation must stop before mechanism begins.

Core questionWhen is mesoscale organisation explained by molecular cooperativity, and when does condensation add explanatory power?

Research directionQuantitative and AI-enabled analysis of nuclear TRIM states across protein architecture, concentration, isoforms and the cell cycle.

TRIM-family architecture, cellular organisation and perturbation map TRIM ARCHITECTURE RINGB-BOXCOIL ORGANISATION PERTURB RESPONSE
Architecture → organisation → perturbationConceptual relationship

Short explainers

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Cellular mesoscale: bodies, filaments, membranes, nuclear foci

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PICNIC: features beyond disorder — developed with the Tóth-Petróczy Lab, MPI-CBG

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TRIM8 syndrome: nephrotic & neurological
Developed with the Majmundar Lab · Boston Children's Hospital

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From a droplet to a kidney
Developed with the Majmundar Lab · Boston Children's Hospital

CENTRAL QUESTION

DAILY REVIEW